Water resources is a crucial environmental good for the function of the human societies and the ecosystems. Moreover, water is an important input for the economy and an indispensable factor for economic growth. Especially in regions that are facing water scarcity, the adoption of water management policies and approaches fostering the sustainable use of resources while promoting economic growth becomes an emerging issue. The Mediterranean region is one of the most vulnerable regions regarding the availability of water resources due to climate change and human activities. The Water-Energy-Food (WEF) Nexus offers an integrated approach analyzing the synergies and trade-offs between the different sectors in order to maximize the efficiency of using the resources,